Measuring device to study biomolecular interactions

This measuring device will allow researchers to determine protein-DNA binding constants within less than 1 hour. In a later phase, the application range will be extended to protein-protein interactions.

BISense

Instead of using a gel, as in a gel shift assay or electrophoretic mobility shift assay (EMSA), our technology relies on a nanopore to detect a mobility shift. As a consequence, our technology

  • is fast: it takes about 1 h per experiment instead of 2-3 days
  • is label-free, eliminating the need for radio-active material or EtBr
  • is easy to use: it requires pipetting buffer solution and different protein and DNA concentrations onto a chip.